MDCRC 642 - Genetics of Complex Diseases

Course work addresses issues relevant to the identification of genes underlying susceptibility to complex disorders. Subjects covered include advantages and disadvantages of isolates versus large population, utilization of affected sibling pairs, discordant sibling pairs and extended families. Methods taught include traditional case-control association methods and family based methods. Other subjects include locus and allelicheterogeneity, phenotypic heterogeneity, gene-gene and gene-environment interactions and density of polymorphic markers.