ANAT 6400 - Fundamentals in Cellular and Molecular Neuroscience

The nervous system is the most complex organ in the body; behavior requires unique cell biology and biochemistry. The goal of this course will be to introduce core cellular and molecular processes in the main brain cell types; neurons and glia. In addition, we will highlight how these processes can go awry in neurological disorders. Topics covered include: Cellular and molecular composition of the nervous system The molecular basis for synaptic transmission – the conversion of electrical activity by chemical synapses. How synapses form circuits during development and learning How synapses signal to the nucleus to regulate gene expression The role of glia (microglia and astrocytes) in brain function. Molecular basis of common neurological disorders New advanced methods to study the brain – optogenetics, human pluripotent stem cells, organoids